Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates

Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates

α-Aminophosphonates are bioisosteres of amino acids and have several pharmacological activities. These compounds have been synthesized by various routes from reaction between amine, aldehyde, and phosphite compounds. In order to synthesize α-aminophosphonates, catalytic effect of CuCl2 was compared with FeCl3. Also all designed structures as well as griseofulvin were docked into the active site...

New aminophosphonates with antioxidative activity.

The antioxidative activity of some newly synthesized aminomethanephosphonic acid derivatives was studied. The compounds studied differed in their polarity and the hydrophobicity of the electronic substituents at their nitrogen and phosphorus atoms. It was found that all the aminophosphonates studied, both cyclic and acyclic, protected erythrocyte membranes against peroxidation to some extent. T...

Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

A simple, efficient, and general method has been developed for the synthesis of various α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, H-NMR, Cand P-NMR spectra. The X-ray crysta...

One-pot synthesis, characterization and of antimicrobial activity of α- aminophosphonates

α-Aminophosphonates (4a-h) were synthesized in one-pot simultaneous reaction of aniline(1), dimethylphosphite(3), and different aromatic aldehydes (2) by Kabachnik–Fields reaction in ethanol at room temperature. The products (4a-h) were obtained in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.

design, synthesis, antifungal and antibacterial activity of some new fluconazole derivatives